casspa.blogg.se - Sodium thiosulfate antidote

Symptoms of cyanate poisoning include headache, confusion, dyspnea, chest tightness, nausea.

There is no widely available, rapid, confirmatory cyanide blood test treatment decisions must be made on basis of clinical history and signs and symptoms of cyanide intoxication.

Presence and extent of cyanide poisoning are often initially unknown.

Sources of cyanide poisoning include hydrogen cyanide and its salts, cyanogenic plants, aliphatic nitriles, and prolonged exposure to sodium nitroprusside.

Cyanide poisoning may result from inhalation, ingestion, or dermal exposure to various cyanide-containing compounds, including smoke from closed-space fires.

If clinical suspicion of cyanide poisoning is high, administer sodium thiosulfate injection without delay.

The safety of administering other cyanide antidotes simultaneously with sodium thiosulfate injection has not been established if a decision is made to administer another cyanide antidote with sodium thiosulfate injection, these drugs should not be administered concurrently in the same intravenous (IV) line.If signs of poisoning reappear, repeat treatment using one-half original dose of both sodium nitrite and sodium thiosulfateĮxpert advice from a regional poison control center may be obtained by calling 1-80 Dosing considerations

Sodium thiosulfate: 50 mL of sodium thiosulfate immediately following administration of sodium nitriteĪirway, ventilatory and circulatory support, and oxygen administration should not be delayed in order to administer sodium nitrite and sodium thiosulfate Sodium Nitrite: 10 mL of sodium nitrite at the rate of 2.5 to 5 mL/minute

Dosage Forms & Strengths injection solutionĬomprehensive treatment of acute cyanide intoxication requires support of vital functions administration of sodium nitrite and sodium thiosulfate should be considered adjunctive to appropriate supportive therapies